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KMID : 1202020080010020142
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Journal of Korean Thyroid Association
2008 Volume.1 No. 2 p.142 ~ p.147
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Characteristics of Papillary Thyroid Microcarcinoma according to Tumor Size
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Tae Kyung
Chung Jae-Ho
Lee Yong-Seop
Choi Yun-Young
Park Yong-Soo
Kim Dong-Sun
Choi Woong-Hwan
Kim Tae-Wha
Ahn You-Hern
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Abstract
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Background and Objectives: Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma measuring less than 10 mm along the greatest dimension. In general, prognosis of the papillary thyroid carcinoma is very favorable, but some PTMC frequently invade the surrounding soft tissue and metastasize to cervical lymph nodes. Optimal therapeutic plan was not established and the treatment strategy of the PTMC has become a subject of debate. Here, we reviewed our experiences and evaluated the characteristics of PTMC that could help in the treatment of PTMC.
Materials and Methods: From January 2000 to December 2006, 354 patients who underwent surgery for papillary thyroid carcinoma were enrolled in this study. Among these patients, 142 patients with PTMC were evaluated. We subdivided the PTMC by size and compared the clinical characteristics in PTMC less than 5 mm and over than 5 mm. And we also compared the clinical characteristics of PTMC with thyroid papillary cancer over than 10 mm.
Results: The mean age of patients at diagnosis was 48.3 years and the female to male ratio was 3.58. PTMC presented with signs of aggressiveness including multifocal disease (19.0%), cervical lymph node metastasis (17.4%), extrathyroid extension (20.4%) and invasion into the adjacent structure including the strap muscle, trachea and recurrent laryngeal nerve (14.0%). The PTMC, more than 5 mm in size, showed a more aggressive feature than PTMC less than 5 mm, especially in lymph node metastasis and extrathyroidal extension.
Conclusion: PTMC showed the signs of aggressiveness with increasing tumor size. These findings suggest that PTMC more than 5 mm needs more extensive treatment than those less than 5 mm.
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KEYWORD
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Thyroid, Papillary Thyroid Microcarcinoma
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